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KMID : 0352720100340040288
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Journal of Ginseng Research
2010 Volume.34 No. 4 p.288 ~ p.295
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Bioconversion of Ginsenoside Rd into Compound K by Lactobacillus pentosus DC101 Isolated from Kimchi
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Quan Lin-Hu
Cheng Le-Qin
Kim Ho-Bin
Kim Ju-Han
Son Na-Ri
Kim Se-Young
Jin Hyun-O
Yang Deok-Chun
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Abstract
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Ginsenosides are the principal components responsible for the pharmacological and biological activities of ginseng. Ginsenoside Rd was transformed into compound K using cell-free extracts of food microorganisms, with Lactobacillus pentosus DC101 isolated from kimchi (traditional Korean fermented food) used for this conversion. The optimum time for the conversion was about 72 h at a constant pH of 7.0 and an optimum temperature of about 30°C. The transformation products were identified by thin-layer chromatography and high-performance liquid chromatography, and their structures were assigned using nuclear magnetic resonance analysis. Generally, ginsenoside Rd was converted into ginsenoside F2 by 36 h post-reaction. Consequently, over 97% of ginsenoside Rd was decomposed and converted into compound K by 72 h post-reaction. The bioconversion pathway to produce compound K is as follows: ginsenoside Rd→ginsenoside F2→compound K.
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KEYWORD
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Bioconversion, Compound K, Ginsenoside modification, Kimchi, Lactobacillus pentosus DC101
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